Nitric oxide (NO) side of lymphatic flow and immune surveillance
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چکیده
منابع مشابه
Nitric oxide (NO) side of lymphatic flow and immune surveillance.
T he loss of cancer or bacteria detection by the immune system is traditionally looked at from the point of cell–cell or humoral mediator–cell interactions. However, immune surveillance in lymphatics critically requires cell transport along the lymphatics for entry of antigen/dendritic cells into the draining lymph node (1). Reductions in collecting lymphatic function affect all subsequent immu...
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We appreciate the opportunity to respond to Michael J. Davis’s Letter (1) regarding our paper “Mechanobiological Oscillators Control Lymph Flow” (2). Our model was developed to study phasic contractions and the dynamics of NO and calcium rather than the control of basal tone. Many factors—in addition to NO—affect lymphatic baseline diameter, including inflammatory cytokines and hormones, and th...
متن کاملNitric oxide and immune response.
Nitric oxide (NO), initially described as a physiological mediator of endothelial cell relaxation plays an important role in hypotension. It is an intercellular messenger and has been recognized as one of the most versatile players in the immune system. Cells of the innate immune system--macrophages, neutrophils and natural killer (NK) cells use pattern recognition receptors to recognize molecu...
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73/ Spring summer 2010, Vol.4, No. 1 Medical Laboratory Journal Correlation between Nitric oxide (NO) & Asymmetric dimethylargininie (ADMA) Hemoglobin Concentration in sickle cell patients Abstract Background and objectives: The importance of Nitric oxide (NO) and Asymmetric dimethylargininie (ADMA) in pathophysiology of Sickle cell disease (SCD) is being increasingly clarified. Since very few ...
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We examined the effects of flow on lymphatic endothelial cells by using conventional cascade preparations of isolated coronary arteries without intact endothelium. The pressurized thoracic ducts were intraluminally perfused at a constant flow rate ranging from 0.5 to 2.0 ml/min. A linear relationship was observed between the flow rate and the normalized amount of relaxing substance(s) released ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1117710109